Filariasis

Lymphatic filariasis, commonly known as Elephantiasis, is mainly caused by W. bancrofti and B. malayi and affects about 120 million people across 80 countries. The definitive parasitologic diagnosis is the demonstration of microfilariae in blood samples. However, this gold standard test is restricted by the requirement for nocturnal blood collection and lack of adequate sensitivity. Detection of circulating antigens is another commercially available diagnostic method, but its usefulness is limited to infection with W. bancrofti. Antibody detection provides an early means to detect filarial parasite infection. Presence of IgM to the parasite antigens suggests current infection, whereas, presence of IgG corresponds to late stage or past infection.

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