- Uses serum, plasma or whole blood specimen
- Utilizes recombinant antigen derived from the CHIK structure protein
- IgM immunoassay is the most practical lab method
- Distinguish from dengue infection which presents with similar symptoms
Clinical performance:
- Sensitivity: 90.4%
- Specificity: 98.0% comparing to a commercial ELISA
- Cross-Reactivity: no cross-reactivity found on 10-40 specimens from the 14 disease states and special conditions, such as dengue, Zika, malaria, HIV, TB, HAV, pregnant woman and others
- No interference with some common substances, such as Acetominophen (20 mg/dL), Heparin (3000 U/L), Ascorbic acid (20 mg/dL), Human IgG (1000 mg/dL), Bilirubin (20 mg/dL), Glucose (55 mmol/L), Creatinine (442 μmol/L), Salicylic acid (4.34 mmol/L), EDTA (3.4 μmol/L), Sodium citrate (3.8%)
