HIV-1 gp120/41 Fusion Antigen
Human Immunodeficiency Virus type I (HIV-1) is a retrovirus transmitted as single-stranded, positive-sense, enveloped RNA virus. The causative relationship between HIV-1 virus and acquired immuno-deficiency syndrome (AIDS) has been established over several decades.
HIV-1 is the main family of HIV and accounts for 95% of all infections worldwide (CDC, 2016). A precursor glycoprotein, gp160, is processed into gp120 and gp41. Three gp120 enveloped glycoproteins are linked together and anchored non-covalently to three gp41 transmembrane molecules, forming an HIV-1 enveloped spike that mediates the attachment and entry of virus to human target cells through multiple interfaces and conserved structural features. Thus, HIV-1 gp120 & 41 are potent immunogens and markers for the serological detection of HIV-1 infection.
A7341 is composed of the gp41 N-terminus fused with the gp120 C-terminus, expressed in E. coli and purified with affinity chromatography.