Treponema pallidum Antigen 47
Treponema pallidum (T. pallidum), a spirochete bacterium, is the causative agent of the venereal disease syphilis, a chronic human disease predominantly transmitted via sexual contact but may also occur between an infected mother and fetus. During 2015, there were over 24,000 primary and secondary cases reported for syphilis, compared to approximately 40,000 people diagnosed with HIV infection in the USA (CDC, 2016).
Tp47 is a T. pallidum highly immunogenic outer membrane lipoprotein and a potent marker for the serological detection of syphilis infection, as it reacts strongly to human anti-syphilis antibody positive sera. A clinical serum case study of 200 patients screened with an rTp47 antigen based ELISA reported a 92% overall agreement with other treponemal tests including fluorescent treponemal antibody absorption (FTA-ABS) and hemagglutination assay (TPHDA).
A0047 is composed of the full length sequence of Tp47, expressed in E.coli and purified with affinity chromatography.