Zika Virus NS1 Antigen

Zika virus (ZIKV) is an RNA member of the Flavivirus genus and is structurally closely related to dengue virus (DENV) and Chikungunya virus. ZIKV can be primarily transmitted by mosquitoes and sexual contact. Severe complications from ZIKV infection include neurological disorders in adults and a variety of fetal abnormalities, including microcephaly and severe brain defects. ZIKV has caused large outbreaks in human populations over the last decade and was recognized as a Public Health Emergency of International Concern (PHEIC) by the World Health Organization (WHO) in February 2016.
ZIKV non-structural protein 1 (NS1) is a ~45 kDa highly conserved secreted glycoprotein, which serves as a major hostinteraction molecule and functions in flaviviral replication, pathogenesis and represents a marker for host immune recognition and evasion2.
A2315 is composed of the full length sequence of Zika NS1, expressed in insect cells and purified with affinity chromatography.

  • Physical                                                 Liquid
  • Concentration                           ≥ 1 mg/mL by Bradford protein assay
  • Storage Buffer                           D-PBS, pH 7.2-7.4
  • Preservatives                              0.099% Thimerosal, 1μg/mL Leupeptin, 1μg/mL Aprotinin, 1μg/mL Pepstatin A and 2.5% D-Trehalose
  • Purity                                                           ≥ 95% on 12.5% SDS-PAGE
  • Purification                                      Affinity chromatography
  • Application                                      Conjugating or coating antigen in ICT and ELISA
  • Cross Reactivity                     N/A